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1

Drosophila eye color mutants as therapeutic tools for Huntington disease

Green, Edward W., Campesan, Susanna, Breda, Carlo, Sathyasaikumar, Korrapati V., Muchowski, Paul J., Schwarcz, Robert, Kyriacou, Charalambos P., Giorgini, Flaviano

Journal:

Year:

2012

Language:

english

File:

PDF, 696 KB

english, 2012

2

A Drosophila RNAi collection is subject to dominant phenotypic effects

Green, Edward W, Fedele, Giorgio, Giorgini, Flaviano, Kyriacou, Charalambos P

Journal:

Year:

2014

Language:

english

File:

PDF, 266 KB

english, 2014

3

The kynurenine pathway and neurodegenerative disease

Maddison, Daniel C., Giorgini, Flaviano

Journal:

Seminars in Cell & Developmental Biology

Year:

2015

Language:

english

File:

PDF, 1.44 MB

english, 2015

4

Author Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntingtonâs disease

Aron, Rebecca, Pellegrini, Pasquale, Green, Edward W., Maddison, Daniel C., Opoku-Nsiah, Kwadwo, Osorio Oliviera, Anna, Wong, Jinny S., Daub, Aaron C., Giorgini, Flaviano, Muchowski, Paul, Finkbeiner,

Journal:

Nature Communications

Year:

2020

Language:

english

File:

PDF, 229 KB

english, 2020

5

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

Giorgini, Flaviano, Guidetti, Paolo, Nguyen, QuangVu, Bennett, Simone C, Muchowski, Paul J

Journal:

Nature Genetics

Year:

2005

Language:

english

File:

PDF, 365 KB

english, 2005

6

Yeast as a drug discovery platform in Huntington's and Parkinson's diseases

Tiago Fleming Outeiro, Flaviano Giorgini

Journal:

Biotechnology Journal

Year:

2006

Language:

english

File:

PDF, 557 KB

english, 2006

7

Yeast as a model for studying human neurodegenerative disorders

Leonor Miller-Fleming, Flaviano Giorgini, Tiago F. Outeiro

Journal:

Biotechnology Journal

Year:

2008

Language:

english

File:

PDF, 357 KB

english, 2008

8

Yeast as a model for studying human neurodegenerative disorders

Leonor Miller-Fleming, Flaviano Giorgini, Tiago F. Outeiro

Journal:

Biotechnology Journal

Year:

2008

Language:

english

File:

PDF, 36 KB

english, 2008

9

The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease

Susanna Campesan, Edward W. Green, Carlo Breda, Korrapati V. Sathyasaikumar, Paul J. Muchowski, Robert Schwarcz, Charalambos P. Kyriacou, Flaviano Giorgini

Journal:

Current Biology

Year:

2011

Language:

english

File:

PDF, 734 KB

english, 2011

10

A Sequence-Specific RNA Binding Complex Expressed in Murine Germ Cells Contains MSY2 and MSY4

Holly G. Davies, Flaviano Giorgini, Mark A. Fajardo, Robert E. Braun

Journal:

Developmental Biology

Year:

2000

Language:

english

File:

PDF, 554 KB

english, 2000

11

Structural basis of kynurenine 3-monooxygenase inhibition

Amaral, Marta, Levy, Colin, Heyes, Derren J., Lafite, Pierre, Outeiro, Tiago F., Giorgini, Flaviano, Leys, David, Scrutton, Nigel S.

Journal:

Year:

2013

Language:

english

File:

PDF, 937 KB

english, 2013

12

Understanding neuronal dysfunction and loss in neurodegenerative disease

Flaviano Giorgini

Journal:

Journal of Molecular Medicine

Year:

2013

Language:

english

File:

PDF, 75 KB

english, 2013

13

Glutathione peroxidase activity is neuroprotective in models of Huntington's disease

Mason, Robert P, Casu, Massimiliano, Butler, Nicola, Breda, Carlo, Campesan, Susanna, Clapp, Jannine, Green, Edward W, Dhulkhed, Devyani, Kyriacou, Charalambos P, Giorgini, Flaviano

Journal:

Nature Genetics

Year:

2013

Language:

english

File:

PDF, 826 KB

english, 2013

14

[Methods in Enzymology] Amyloid, Prions, and Other Protein Aggregates, Part B Volume 412 || Screening for Genetic Modifiers of Amyloid Toxicity in Yeast

Giorgini, Flaviano

Year:

2006

Language:

english

File:

PDF, 438 KB

english, 2006

15

Connecting the dots in Huntington's disease with protein interaction networks

Flaviano Giorgini,Paul J Muchowski

Journal:

Year:

2005

Language:

english

File:

PDF, 97 KB

english, 2005

16

A flexible polyglutamine hinge opens new doors for understanding huntingtin function: Fig. 1.

Giorgini, Flaviano

Journal:

Proceedings of the National Academy of Sciences

Year:

2013

Language:

english

File:

PDF, 614 KB

english, 2013

17

Choosing and using Drosophila models to characterize modifiers of Huntington's disease

Green, Edward W., Giorgini, Flaviano

Journal:

Biochemical Society Transactions

Year:

2012

Language:

english

File:

PDF, 302 KB

english, 2012

18

The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network

Uthman, Shanow, Bär, Christian, Scheidt, Viktor, Liu, Shihui, ten Have, Sara, Giorgini, Flaviano, Stark, Michael J. R., Schaffrath, Raffael, Andersen, Gregers Rom.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.97 MB

english, 2013

19

Modeling Huntington disease in yeast: Perspectives and future directions

Mason, Robert P., Giorgini, Flaviano

Journal:

Year:

2011

Language:

english

File:

PDF, 824 KB

english, 2011

20

Is modulating translation a therapeutic option for Huntington’s disease?

Giorgini, Flaviano

Journal:

Neurodegenerative Disease Management

Year:

2011

Language:

english

File:

PDF, 1.00 MB

english, 2011

21

Rab11 as a modulator of synaptic transmission

Giorgini, Flaviano, Steinert, Joern R

Journal:

Communicative & Integrative Biology

Year:

2013

Language:

english

File:

PDF, 739 KB

english, 2013

22

Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington’s disease models

Smalley, Joshua L., Breda, Carlo, Mason, Robert P., Kooner, Gurdeep, Luthi-Carter, Ruth, Gant, Timothy W., Giorgini, Flaviano

Journal:

Journal of Molecular Medicine

Year:

2016

Language:

english

File:

PDF, 1.34 MB

english, 2016

23

Metallothioneins and copper metabolism are candidate therapeutic targets in Huntington's disease

Hands, Sarah L., Mason, Robert, Sajjad, M. Umar, Giorgini, Flaviano, Wyttenbach, Andreas

Journal:

Biochemical Society Transactions

Year:

2010

Language:

english

File:

PDF, 288 KB

english, 2010

24

Glycation potentiates neurodegeneration in models of Huntington’s disease

Vicente Miranda, Hugo, Gomes, Marcos António, Branco-Santos, Joana, Breda, Carlo, Lázaro, Diana F., Lopes, Luísa Vaqueiro, Herrera, Federico, Giorgini, Flaviano, Outeiro, Tiago Fleming

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.41 MB

english, 2016

25

Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity

Branco-Santos, Joana, Herrera, Federico, Poças, Gonçalo M., Pires-Afonso, Yolanda, Giorgini, Flaviano, Domingos, Pedro M., Outeiro, Tiago F.

Journal:

Human Molecular Genetics

Year:

2017

Language:

english

File:

PDF, 4.74 MB

english, 2017

26

SIRT 3 , a modifier of mitochondrial function in Huntington's disease

Naia, Luana, Carmo, Catarina, Campesan, Susanna, Lopes, Carla, Valero, Jorge, Rosenstock, Tatiana R., Giorgini, Flaviano, Cristina Rego, A.

Journal:

Free Radical Biology and Medicine

Year:

2018

Language:

english

File:

PDF, 41 KB

english, 2018

27

A Novel Sit4 Phosphatase Complex Is Involved in the Response to Ceramide Stress in Yeast

Woodacre, Alexandra, Lone, Museer A., Jablonowski, Daniel, Schneiter, Roger, Giorgini, Flaviano, Schaffrath, Raffael

Journal:

Oxidative Medicine & Cellular Longevity

Year:

2013

Language:

english

File:

PDF, 2.55 MB

english, 2013

28

Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease

Aron, Rebecca, Pellegrini, Pasquale, Green, Edward W., Maddison, Daniel C., Opoku-Nsiah, Kwadwo, Wong, Jinny S., Daub, Aaron C., Giorgini, Flaviano, Finkbeiner, Steven

Journal:

Nature Communications

Year:

2018

Language:

english

File:

PDF, 1.98 MB

english, 2018

29

Publisher Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease

Aron, Rebecca, Pellegrini, Pasquale, Green, Edward W., Maddison, Daniel C., Opoku-Nsiah, Kwadwo, Wong, Jinny S., Daub, Aaron C., Giorgini, Flaviano, Finkbeiner, Steven

Journal:

Nature Communications

Year:

2018

Language:

english

File:

PDF, 236 KB

english, 2018

30

Maternal genotype determines kynurenic acid levels in the fetal brain: Implications for the pathophysiology of schizophrenia

Beggiato, Sarah, Notarangelo, Francesca M, Sathyasaikumar, Korrapati V, Giorgini, Flaviano, Schwarcz, Robert

Journal:

Journal of Psychopharmacology

Year:

2018

Language:

english

File:

PDF, 471 KB

english, 2018

31

Drosophila Nrf2/Keap1 Mediated Redox Signaling Supports Synaptic Function and Longevity and Impacts on Circadian Activity

Spiers, Jereme G., Breda, Carlo, Robinson, Sue, Giorgini, Flaviano, Steinert, Joern R.

Journal:

Frontiers in Molecular Neuroscience

Year:

2019

Language:

english

File:

PDF, 3.09 MB

english, 2019

32

Publisher Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntingtonâs disease

Aron, Rebecca, Pellegrini, Pasquale, Green, Edward W., Maddison, Daniel C., Opoku-Nsiah, Kwadwo, Oliveira, Anna Osorio, Wong, Jinny S., Daub, Aaron C., Giorgini, Flaviano, Muchowski, Paul, Finkbeiner,

Journal:

Nature Communications

Year:

2020

File:

PDF, 253 KB

2020

33

RAB39B is redistributed in dementia with lewy bodies and is sequestered within AÎ² plaques and lewy bodies

Koss, David J., Bondarevaite, Odeta, Adams, Sara, Leite, Marta, Giorgini, Flaviano, Attems, Johannes, Outeiro, Tiago F.

Journal:

Brain Pathology

Year:

2020

File:

PDF, 1.48 MB

2020

34

Rab8 Promotes Mutant HTT Aggregation, Reduces Neurodegeneration, and Ameliorates Behavioural Alterations in a Drosophila Model of Huntingtonâs Disease

Delfino, Laura, Mason, Robert P., Kyriacou, Charalambos P., Giorgini, Flaviano, Rosato, Ezio

Journal:

Journal of Huntington's Disease

Year:

2020

File:

PDF, 725 KB

2020

35

[BMJ Publishing Group Ltd EHDN 2018 Plenary Meeting, Vienna, Austria, Programme and Abstracts - ()] Pathogenic mechanisms - A47âQuantitative trait locus analysis in yeast: identifying candidate therapeutic targets for huntingtonâs disease

Alfonso-NÃºÃ±ez, MÃ³nica, Louis, Edward J, Giorgini, Flaviano

Year:

2018

File:

PDF, 51 KB

2018

36

Advantages of brain penetrating inhibitors of kynurenine-3-monooxygenase for treatment of neurodegenerative diseases

Zhang, Shaowei, Collier, Mary E.W., Heyes, Derren J., Giorgini, Flaviano, Scrutton, Nigel S.

Journal:

Archives of Biochemistry and Biophysics

Year:

2021

File:

PDF, 2.36 MB

2021

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